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ActoPlus Met (pioglitazone, metformin) is a combination anti-diabetic tablet, widely used among individuals who have type 2 diabetes. Lifestyle changes are also advised, including modifying diet and getting regular exercise.

Effects of this product on unborn or nursing babies are unclear; mothers should not buy ActoPlus Met if pregnant or breastfeeding without first discussing potential risks with a doctor.

This medication is not effective for type 1 diabetes.

Product Overview

Patients who buy ActoPlus Met will receive tablets, each of which contains both pioglitazone and metformin. Both of these ingredients are beneficial in treating type 2 diabetes:

  • Pioglitazone makes insulin in the body work more effectively, ultimately reducing overall glucose levels.
  • Metformin also lowers overall glucose levels, primarily by inhibiting its production, reducing its absorption from food, and increasing its absorption by cells.

Both pioglitazone and metformin are available on their own, though most patients taking both prefer to have them in a single convenient tablet.

Patients thinking about buying ActoPlus Met for the first time should be aware of the controversies with this product, in particular with pioglitazone. Some studies indicate that patients who take pioglitazone for more than one year have an increased risk of bladder cancer, and as a result the drug was withdrawn from the market in some European countries. Other studies find no such connection between pioglitazone and bladder cancer, and the drug remains widely used.

Ultimately the decision to buy ActoPlus Met is a personal one. Discussing potential risks with a trusted doctor will also help.

Dosage & Administration

While there are exceptions, most patients who buy ActoPlus Met have committed to lifestyle changes and generally do not also take insulin. Some patients do take both ActoPlus Met and insulin, however, and the medication will provide some benefit even without lifestyle changes.

Tablets are typically taken once or twice per day, in some cases three times per day. It depends on dosage, which ranges from 15 mg pioglitazone and 500 mg metformin to 45 mg pioglitazone and 2550 mg metformin.

In most cases treatment looks like:

  • Start with 15/500 mg pioglitazone/metformin once or twice per day.
  • Dosage may be gradually titrated higher if needed, assuming the medication is well tolerated.
  • Do not exceed 45 mg pioglitazone or 2550 mg metformin in one day

Patients should monitor blood sugar closely at the start of treatment and following any dosage adjustments. Patients won't feel particularly different unless blood glucose becomes significantly low or high---both of which warrant medical attention---but ideally blood glucose will fall within normal ranges. It is important that blood sugar be kept within normal ranges to prevent an assortment of negative complications, some of which can be very painful, detract from independence and quality of life, or even be fatal.

It's also important to attend regular doctor checkups to ensure the medication is working as intended. Doctors will also be able to monitor for developing complications---either the result of ActoPlus Met or type 2 diabetes---and address them as needed. Most complications are significantly easier to manage if caught early.

Lifestyle Changes

Patients who buy ActoPlus Met will most likely be advised to make lifestyle changes as well. These vary from patient to patient and also by location, but in general are fairly similar:

  • Improve diet
  • Get regular exercise
  • Reach or maintain a healthy weight
  • Manage high cholesterol
  • Manage high blood pressure
  • Quit smoking

Rarely some individuals make and maintain significant lifestyle changes but see little difference in diabetes. Others are unable or unwilling to make or maintain such changes. ActoPlus Met will still provide benefit in these cases, but not as significantly as when lifestyle changes are implemented.

In fact lifestyle changes are often the only way to control the condition without medications; if made and maintained, treatment with ActoPlus Met---or any other anti-diabetic medication---may eventually end. Otherwise treatment will likely need to continue for the remainder of life.

Better Health Delivered to your Door

Patients who buy ActoPlus Met are taking a significant step toward improving their overall health, maintaining a high quality of life, and perhaps extending life itself. And when you buy from Kiwi Drug, you'll also receive peace of mind knowing your order is in the experienced hands of New Zealand's oldest and most-trusted online pharmacy. We're subject to the same regulatory oversight as our real-world counterparts, and your personal data is protected with state-of-the-art security software.

Clients will need a prescription to buy ActoPlus Met. If you don't have one, you're welcome to take advantage of our online doctor services for no additional charge. Simply add the product to your cart, initiate checkout, and answer the questions about your medical history and other medications being taken to see if you qualify.

Patients who already have a prescription to buy ActoPlus Met will be given options to transfer it to us after completing checkout.

Please don't hesitate to drop us a line if you have any questions or encounter a problem with your order.



**Important note for patrons: The information on this page is not official label or safety information as written by the manufacturer or reviewed by the FDA. We only list for sale and refer orders to our affiliates for medications approved in the country where they are licensed, and any product requiring a prescription must be sold under the direction of a licensed physician.
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